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Antihistamines: The potentially ‘life-threatening’ side effect that can cause ‘disability’

Medscape explains that the classic triad of the condition comprises myalgia, generalised weakness and darkened urine.

The presentations of rhabdomyolysis can vary considerably, however, causing other symptoms like fever, nausea and vomiting.

The initial presentations, which can be non-specific, include:

  • Muscle pain and tenderness
  • Decreased muscle strength
  • Soft tissue swelling
  • Skin changes consistent with pressure necrosis
  • Hyperthermia, hypothermia and electrical injury
  • Crush injuries or deformities in long bones.

The treatment of these symptoms will typically start with the intravenous admission of fluids and electrolytes, which aim to flush toxins from the system.


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