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Technology

Advancements in Endometriosis Diagnosis: Promising Findings from 99mTc-Maraciclatide Imaging Study”

The presentation provided a concise Endometriosis overview of preliminary findings stemming from the imaging of patients with confirmed or suspected endometriosis using a SPECT-CT camera. Subsequently, these patients underwent laparoscopic surgery, a minimally invasive procedure aimed at identifying the presence, absence, and location of endometriotic lesions. The comparison between imaging findings and surgical/histology reports suggests that 99mTc-maraciclatide exhibits potential as a non-invasive diagnostic tool for early-stage endometriosis.

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Endometriosis

Detection of superficial peritoneal endometriosis, a subtype primarily located in the thin peritoneum lining covering the abdomen and pelvis. Traditionally, accurate identification of this subtype required surgical intervention. However, in the study, 99mTc-maraciclatide successfully identified superficial peritoneal endometriosis in patients later confirmed to have this early-stage condition through laparoscopy.

Identification of areas of activity in patients with deep endometriosis, often affecting organs such as the bladder, bowel, rectum, and ovaries, as well as endometrioma (ovarian cysts).

Additionally, the presentation highlighted a case study involving a patient with superficial peritoneal endometriosis, initially undetected by ultrasound but visualized with 99mTc-maraciclatide and later confirmed during laparoscopic surgery.

The ongoing study, led by Professor Christian Becker and Professor Krina Zondervan of the University of Oxford, aims to recruit 20-25 patients in total and is expected to conclude later this year.

99mTc-maraciclatide, a radio-labeled tracer targeting the αvβ3 integrin cell adhesion protein, facilitates the imaging of angiogenesis (new blood vessel formation), a process crucial for the development and growth of endometriotic lesions.

David Hail, CEO of Serac Healthcare, expressed optimism regarding the initial findings, emphasizing the potential of maraciclatide as a novel non-invasive diagnostic tool for early-stage endometriosis. Given the significant delay in diagnosing the disease using current imaging modalities, these findings offer hope for earlier and more accurate diagnosis, thereby reducing patients’ suffering and uncertainty.

Professors Becker and Zondervan underscored the importance of early diagnosis, particularly for superficial peritoneal endometriosis, which predominantly affects younger women. Early intervention facilitated by timely diagnosis could lead to improved outcomes and prospects for affected individuals.

In conclusion, the promising results of the DETECT study represent a significant step forward in the quest for more effective diagnostic tools for endometriosis, with the potential to positively impact millions of women worldwide.

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